Intangible Assets and Goodwill (Tables)

12 Months Ended

Dec. 31, 2025

Goodwill and Intangible Assets Disclosure [Abstract]

Intangible assets

Intangible assets, net of accumulated amortization, impairment charges and adjustments are summarized as follows:

		As of December 31, 2025						As of December 31, 2024
(In millions)	Estimated Life	Cost		Accumulated Amortization		Net		Cost		Accumulated Amortization		Net
Completed technology	1-30 years	$	14,067.3	$	(6,687.8)	$	7,379.5	$	14,138.4	$	(6,254.1)	$	7,884.3
In-process research and development	Indefinite until commercialization	1,635.0		—		1,635.0		1,642.9		—		1,642.9
Priority review voucher	Indefinite	100.0		—		100.0		100.0		—		100.0
Trademarks and trade names	Indefinite	64.0		—		64.0		64.0		—		64.0
Total intangible assets		$	15,866.3	$	(6,687.8)	$	9,178.5	$	15,945.3	$	(6,254.1)	$	9,691.2

Estimated future amortization of intangible assets

The estimated future amortization of finite-lived intangible assets for the next five years is expected to be as follows:

(In millions)	As of December 31, 2025
2026	$	485.0
2027	485.0
2028	525.0
2029	575.0
2030	645.0

Summary of roll forward of the changes in goodwill

The following table provides a roll forward of the changes in our goodwill balance:

	As of December 31,
(In millions)	2025		2024
Goodwill, January 1	$	6,478.9	$	6,219.2
Goodwill resulting from HI-Bio acquisition(1)	4.5		256.5
Goodwill resulting from Reata acquisition(2)	—		4.7
Other(3)	7.7		(1.5)
Goodwill, December 31	$	6,491.1	$	6,478.9

(1) Goodwill resulting from the HI-Bio acquisition for the year ended December 31, 2025, relates to HI-Bio measurement period adjustments recognized during 2025.

(2) Goodwill resulting from the Reata acquisition for the year ended December 31, 2024, relates to Reata measurement period adjustments recognized during 2024.

(3) Other includes adjustments related to foreign currency exchange rate fluctuations.