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Collaborative and Other Relationships - Ionis (Details)
shares in Millions, $ in Millions
1 Months Ended 12 Months Ended
Apr. 30, 2023
Dec. 31, 2019
USD ($)
Jun. 30, 2018
USD ($)
shares
Sep. 30, 2013
Dec. 31, 2012
geneTarget
Dec. 31, 2025
USD ($)
Dec. 31, 2024
USD ($)
Dec. 31, 2023
USD ($)
Dec. 31, 2017
USD ($)
Collaborative arrangements and non-collaborative arrangement transactions                  
Cost of sales, excluding amortization and impairment of acquired intangible assets           $ 2,404.2 $ 2,310.4 $ 2,533.4  
Research and development           1,778.6 1,980.3 2,445.4  
Ionis Pharmaceuticals                  
Collaborative arrangements and non-collaborative arrangement transactions                  
Term of collaboration agreement     10 years 6 years          
Total payment to enter collaboration agreement     $ 1,000.0            
Upfront payment for collaboration agreement     $ 375.0            
Investment in common stock, shares purchased (in shares) | shares     11.5            
Purchase of common stock     $ 625.0            
Estimated additional payments upon achievement of development and commercial milestones                 $ 155.0
Research and development           7.5 7.5 7.5  
Expected additional milestone payments when certain sales threshold is met                 $ 400.0
Gene targets | geneTarget         3        
Additional milestone payment   $ 155.0              
Ionis Pharmaceuticals | SPINRAZA                  
Collaborative arrangements and non-collaborative arrangement transactions                  
Cost of sales, excluding amortization and impairment of acquired intangible assets           $ 212.3 216.1 240.2  
Ionis Pharmaceuticals | SOD1                  
Collaborative arrangements and non-collaborative arrangement transactions                  
Research and development               $ 16.0  
Ionis Pharmaceuticals | QALSODY                  
Collaborative arrangements and non-collaborative arrangement transactions                  
Research and development             20.0    
Ionis Pharmaceuticals | QALSODY Japan                  
Collaborative arrangements and non-collaborative arrangement transactions                  
Research and development             $ 10.0    
Ionis Pharmaceuticals | Minimum                  
Collaborative arrangements and non-collaborative arrangement transactions                  
Estimated additional payments upon achievement of development and commercial milestones     125.0            
Ionis Pharmaceuticals | Minimum | SPINRAZA                  
Collaborative arrangements and non-collaborative arrangement transactions                  
Percentage of royalties as per collaboration           11.00%      
Ionis Pharmaceuticals | Minimum | QALSODY                  
Collaborative arrangements and non-collaborative arrangement transactions                  
Percentage of royalties as per collaboration 11.00%                
Ionis Pharmaceuticals | Maximum                  
Collaborative arrangements and non-collaborative arrangement transactions                  
Estimated additional payments upon achievement of development and commercial milestones     $ 270.0            
Ionis Pharmaceuticals | Maximum | SPINRAZA                  
Collaborative arrangements and non-collaborative arrangement transactions                  
Percentage of royalties as per collaboration           15.00%      
Ionis Pharmaceuticals | Maximum | QALSODY                  
Collaborative arrangements and non-collaborative arrangement transactions                  
Percentage of royalties as per collaboration 15.00%                
Ionis Pharmaceuticals Inc.                  
Collaborative arrangements and non-collaborative arrangement transactions                  
Estimated additional payments upon initiation of new phases           $ 45.0