Restructuring, Business Transformation and Other Cost Saving Initiatives (Tables)

3 Months Ended

Mar. 31, 2025

Restructuring and Related Activities [Abstract]

Restructuring and Related Costs

Total charges incurred from our 2023 Fit for Growth program are summarized as follows:

	For the Three Months Ended March 31,
	2025						2024
(In millions)	Severance Costs		Accelerated Depreciation and Other Costs		Total		Severance Costs		Accumulated Depreciation and Other Costs		Total
Selling, general and administrative	$	—	$	(3.9)	$	(3.9)	$	—	$	1.4	$	1.4
Research and development	—		5.1		5.1		—		4.9		4.9
Restructuring charges	35.3		—		35.3		9.3		—		9.3
Total charges	$	35.3	$	1.2	$	36.5	$	9.3	$	6.3	$	15.6

Total charges incurred from our Reata integration are summarized as follows:

	For the Three Months Ended March 31,
	2025						2024
(In millions)	Severance Costs		Accelerated Depreciation and Other Costs		Total		Severance Costs		Accumulated Depreciation and Other Costs		Total
Selling, general and administrative	$	—	$	1.8	$	1.8	$	—	$	1.8	$	1.8
Research and development	—		2.3		2.3		—		2.7		2.7
Restructuring charges	(0.2)		—		(0.2)		2.2		—		2.2
Total charges	$	(0.2)	$	4.1	$	3.9	$	2.2	$	4.5	$	6.7

Schedule of Restructuring Reserve by Type of Cost

Charges and spending related to workforce reductions are summarized as follows:

	Workforce Reductions
(In millions)	2025		2024
Restructuring reserve as of January 1	$	31.9	$	75.4
Expense	35.3		11.5
Payment	(25.8)		(42.2)
Foreign currency and other adjustments	(1.0)		0.8
Restructuring reserve as of March 31	$	40.4	$	45.5