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Insider Trading Arrangements
shares in Thousands
 3 Months Ended
Mar. 31, 2025
shares
Trading Arrangements, by Individual  
Material Terms of Trading Arrangement During the first quarter of 2025 our officers and directors took the following actions with respect to trading arrangements:
Trading Arrangement
Name and PositionActionDateRule
10b5-1		Non-Rule 10b5-1Total Shares to be Purchased or SoldExpiration Date
Priya Singhal, M.D., EVP, Head of Development
Adopt2/18/2025X—19,5232/27/2026
Rachid Izzar, EVP, Global Product Strategy and Commercialization
Adopt3/12/2025X—2,2238/18/2025
Stephen Sherwin, Director
Adopt2/24/2025X—4,3798/24/2025
Non-Rule 10b5-1 Arrangement Adopted false
Rule 10b5-1 Arrangement Terminated false
Non-Rule 10b5-1 Arrangement Terminated false
Priya Singhal, M.D. [Member]  
Trading Arrangements, by Individual  
Name Priya Singhal, M.D.
Title EVP, Head of Development
Rule 10b5-1 Arrangement Adopted true
Adoption Date 2/18/2025
Expiration Date 2/27/2026
Arrangement Duration 374 days
Aggregate Available 19,523,000
Rachid Izzar [Member]  
Trading Arrangements, by Individual  
Name Rachid Izzar
Title EVP, Global Product Strategy and Commercialization
Rule 10b5-1 Arrangement Adopted true
Adoption Date 3/12/2025
Expiration Date 8/18/2025
Arrangement Duration 159 days
Aggregate Available 2,223,000
Stephen Sherwin [Member]  
Trading Arrangements, by Individual  
Name Stephen Sherwin
Title Director
Rule 10b5-1 Arrangement Adopted true
Adoption Date 2/24/2025
Expiration Date 8/24/2025
Arrangement Duration 181 days
Aggregate Available 4,379,000