Restructuring - Narrative (Details) employee in Thousands, $ in Millions		12 Months Ended
	Sep. 26, 2023 USD ($) ft²	Dec. 31, 2024 USD ($)	Dec. 31, 2023 USD ($) employee
Maximum
Restructuring Cost and Reserve [Line Items]
Expected cost remaining			$ 280.0
Operating lease, contract term		14 years
Minimum
Restructuring Cost and Reserve [Line Items]
Expected cost remaining			$ 260.0
Operating lease, contract term		1 year
2023 Cost Saving Initiatives
Restructuring Cost and Reserve [Line Items]
Expected operating expense reduction	$ 1,000.0
Expected number of positions eliminated | employee			1
Reata Integration
Restructuring Cost and Reserve [Line Items]
Expected cost		$ 35.0
Reata Pharmaceuticals, Inc
Restructuring Cost and Reserve [Line Items]
Operating lease area | ft²	327,400
Operating lease, contract term	16 years
Human Immunology Biosciences
Restructuring Cost and Reserve [Line Items]
Integration related costs		$ 2.6