Restructuring (Tables)

12 Months Ended

Dec. 31, 2024

Restructuring and Related Activities [Abstract]

Restructuring and related costs

Total charges incurred from our 2023 Fit for Growth program are summarized as follows:

	For the Years Ended December 31,
	2024						2023
(In millions)	Severance Costs		Accelerated Depreciation and Other Costs		Total		Severance Costs		Accelerated Depreciation and Other Costs		Total
Selling, general and administrative	$	—	$	13.8	$	13.8	$	—	$	23.3	$	23.3
Research and development	—		11.7		11.7		—		1.2		1.2
Restructuring charges	24.2		—		24.2		153.4		34.6		188.0
Total charges	$	24.2	$	25.5	$	49.7	$	153.4	$	59.1	$	212.5

Total charges incurred from our Reata integration are summarized as follows:

	For the Years Ended December 31,
	2024						2023
(In millions)	Severance Costs		Accelerated Depreciation and Other Costs		Total		Severance Costs		Accelerated Depreciation and Other Costs		Total
Selling, general and administrative	$	—	$	6.3	$	6.3	$	—	$	—	$	—
Research and development	—		11.9		11.9		—		—		—
Restructuring charges	3.4		—		3.4		30.4		—		30.4
Total charges	$	3.4	$	18.2	$	21.6	$	30.4	$	—	$	30.4

Total charges incurred from our 2022 cost saving initiatives are summarized as follows:

	For the Years Ended December 31,
	2023						2022
(In millions)	Severance Costs		Accelerated Depreciation and Other Costs		Total		Severance Costs		Accumulated Depreciation and Other Costs(1)		Total
Restructuring charges	$	(2.2)	$	2.6	$	0.4	$	112.6	$	18.5	$	131.1
Total charges	$	(2.2)	$	2.6	$	0.4	$	112.6	$	18.5	$	131.1

(1) Amounts reflect a gain recorded during the third quarter of 2022 of approximately $5.3 million related to the partial termination of a portion of our lease located at 300 Binney Street. For additional information on our 300 Binney Street lease modification, please read Note 12, Leases, to these consolidated financial statements.

Schedule of restructuring reserve by type of cost

Charges and spending related to workforce reductions are summarized as follows:

(In millions)	Workforce Reductions
Restructuring reserve, December 31, 2022	$	35.9
Expense	181.6
Payment	(140.5)
Foreign currency and other adjustments	(1.6)
Restructuring reserve, December 31, 2023	75.4
Expense	30.2
Payment	(73.8)
Foreign currency and other adjustments	0.1
Restructuring reserve, December 31, 2024	$	31.9