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Collaborative and Other Relationships - Other Arrangements (Details) - USD ($)
$ / shares in Units, shares in Millions, $ in Millions
1 Months Ended 3 Months Ended 12 Months Ended
Dec. 31, 2020
Sep. 30, 2020
Apr. 30, 2020
Dec. 31, 2019
Dec. 31, 2023
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Collaborative arrangements and non-collaborative arrangement transactions                
Share of net profit from sage therapeutics, percent           50.00%    
Research and development           $ 2,041.8 $ 2,462.0 $ 2,231.1
Sage Therapeutics                
Collaborative arrangements and non-collaborative arrangement transactions                
Global licensing collaboration, shares purchased, amount $ 650.0              
Global licensing collaboration, shares purchased (in shares) 6.2              
Global licensing collaboration, purchase price per share (in dollars per share) $ 104.14              
Global licensing collaboration, development and commercial milestone payments $ 700.0              
Research and development expense         $ 75.0      
Expected profit share percentage           50.00%    
Collaboration profit (loss) sharing           $ 27.0 4.7  
Denali Therapeutics                
Collaborative arrangements and non-collaborative arrangement transactions                
Global licensing collaboration, shares purchased, amount   $ 465.0            
Global licensing collaboration, shares purchased (in shares)   13.0            
Global licensing collaboration, purchase price per share (in dollars per share)   $ 34.94            
Global licensing collaboration, development and commercial milestone payments   $ 1,100.0            
Sangamo Therapeutics, Inc. Agreement                
Collaborative arrangements and non-collaborative arrangement transactions                
Global licensing collaboration, shares purchased, amount     $ 225.0          
Global licensing collaboration, shares purchased (in shares)     24.0          
Global licensing collaboration, purchase price per share (in dollars per share)     $ 9.21          
Other research and discovery                
Collaborative arrangements and non-collaborative arrangement transactions                
Research and development           $ 54.0 $ 4.1 $ 39.2
Samsung Bioepis                
Collaborative arrangements and non-collaborative arrangement transactions                
Expected profit share percentage       45.00%   50.00%