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- Definition

Estimated additional payments upon achievement of development and commercial milestones.

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- Definition

Expected additional milestone payments when meeting certain sales threshold.

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- Definition

Expected license fee and regulatory milestone payments.

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No definition available.

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- Definition

Investment In Common Stock, Shares Purchased

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- Definition

License Fee

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No definition available.

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- Definition

Percentage of royalties as per collaboration.

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No definition available.

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- Definition

Purchase of common stock

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- Definition

Research And Development, Gene Targets

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- Definition

Term Of Collaboration Agreement

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- Definition

Total payment to enter collaboration agreement

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- Definition

Upfront Payment For Collaboration Agreement

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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- Definition

The aggregate costs related to goods produced and sold and services rendered by an entity during the reporting period. This excludes costs incurred during the reporting period related to financial services rendered and other revenue generating activities.

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Amount of expense for research and development. Includes, but is not limited to, cost for computer software product to be sold, leased, or otherwise marketed and writeoff of research and development assets acquired in transaction other than business combination or joint venture formation or both. Excludes write-down of intangible asset acquired in business combination or from joint venture formation or both, used in research and development activity.

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Collaborative and Other Relationships - Ionis (Details) shares in Millions, $ in Millions	1 Months Ended					12 Months Ended
	Apr. 30, 2023	Dec. 31, 2019 USD ($)	Jun. 30, 2018 USD ($) shares	Sep. 30, 2013 USD ($)	Dec. 31, 2012 USD ($) geneTarget	Dec. 31, 2024 USD ($)	Dec. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)	Dec. 31, 2017 USD ($)
Collaborative arrangements and non-collaborative arrangement transactions
Cost of sales, excluding amortization and impairment of acquired intangible assets						$ 2,310.4	$ 2,533.4	$ 2,278.3
Research and development						2,041.8	2,462.0	2,231.1
Ionis Pharmaceuticals
Collaborative arrangements and non-collaborative arrangement transactions
Term of collaboration agreement			10 years	6 years
Total payment to enter collaboration agreement			$ 1,000.0
Upfront payment for collaboration agreement			$ 375.0
Investment in common stock, shares purchased (in shares) \| shares			11.5
Purchase of common stock			$ 625.0
Estimated additional payments upon achievement of development and commercial milestones									$ 260.0
Research and development						7.5	7.5	10.0
Expected additional milestone payments when certain sales threshold is met									$ 800.0
License fee				$ 70.0	$ 70.0
Expected license fee and regulatory milestone payments				$ 130.0	$ 130.0
Research and development expense		$ 45.0
Gene targets \| geneTarget					3
Additional milestone payment		$ 155.0
Ionis Pharmaceuticals \| SPINRAZA
Collaborative arrangements and non-collaborative arrangement transactions
Cost of sales, excluding amortization and impairment of acquired intangible assets						216.1	240.2	243.1
Ionis Pharmaceuticals \| SOD1
Collaborative arrangements and non-collaborative arrangement transactions
Research and development								17.0
Ionis Pharmaceuticals \| BIIB080
Collaborative arrangements and non-collaborative arrangement transactions
Research and development expense								$ 10.0
Ionis Pharmaceuticals \| QALSODY
Collaborative arrangements and non-collaborative arrangement transactions
Research and development							$ 16.0
Ionis Pharmaceuticals \| QALSODY EU
Collaborative arrangements and non-collaborative arrangement transactions
Research and development						20.0
Ionis Pharmaceuticals \| QALSODY Japan
Collaborative arrangements and non-collaborative arrangement transactions
Research and development						$ 10.0
Ionis Pharmaceuticals \| Minimum
Collaborative arrangements and non-collaborative arrangement transactions
Estimated additional payments upon achievement of development and commercial milestones			125.0
Ionis Pharmaceuticals \| Minimum \| SPINRAZA
Collaborative arrangements and non-collaborative arrangement transactions
Percentage of royalties as per collaboration						11.00%
Ionis Pharmaceuticals \| Minimum \| QALSODY
Collaborative arrangements and non-collaborative arrangement transactions
Percentage of royalties as per collaboration	11.00%
Ionis Pharmaceuticals \| Maximum
Collaborative arrangements and non-collaborative arrangement transactions
Estimated additional payments upon achievement of development and commercial milestones			$ 270.0
Ionis Pharmaceuticals \| Maximum \| SPINRAZA
Collaborative arrangements and non-collaborative arrangement transactions
Percentage of royalties as per collaboration						15.00%
Ionis Pharmaceuticals \| Maximum \| QALSODY
Collaborative arrangements and non-collaborative arrangement transactions
Percentage of royalties as per collaboration	15.00%