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Collaborative and Other Relationships - Other Arrangements (Details) - USD ($)
$ / shares in Units, shares in Millions, $ in Millions
1 Months Ended 3 Months Ended 12 Months Ended
Aug. 31, 2021
Dec. 31, 2020
Sep. 30, 2020
Apr. 30, 2020
Dec. 31, 2023
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Collaborative arrangements and non-collaborative arrangement transactions                
Potential future milestone payments commitment to third party approximately         $ 5,100.0 $ 5,100.0    
Share of net profit from sage therapeutics, percent         50.00% 50.00%    
Research and development           $ 2,462.0 $ 2,231.1 $ 2,501.2
Sage Therapeutics                
Collaborative arrangements and non-collaborative arrangement transactions                
Global licensing collaboration, shares purchased, amount   $ 650.0            
Global licensing collaboration, shares purchased (in shares)   6.2            
Global licensing collaboration, purchase price per share (in dollars per share)   $ 104.14            
Global licensing collaboration, development and commercial milestone payments   $ 1,600.0            
Research and development expense asset acquired         $ 75.0      
Collaboration profit (loss) sharing           4.7    
Denali Therapeutics                
Collaborative arrangements and non-collaborative arrangement transactions                
Global licensing collaboration, shares purchased, amount     $ 465.0          
Global licensing collaboration, shares purchased (in shares)     13.0          
Global licensing collaboration, purchase price per share (in dollars per share)     $ 34.94          
Global licensing collaboration, development and commercial milestone payments     $ 1,100.0          
Sangamo Therapeutics, Inc. Agreement                
Collaborative arrangements and non-collaborative arrangement transactions                
Global licensing collaboration, shares purchased, amount       $ 225.0        
Global licensing collaboration, shares purchased (in shares)       24.0        
Global licensing collaboration, purchase price per share (in dollars per share)       $ 9.21        
InnoCare Pharma Limited (InnoCare) Agreement                
Collaborative arrangements and non-collaborative arrangement transactions                
Upfront and milestone payments made to collaborative partner $ 125.0              
Other research and discovery                
Collaborative arrangements and non-collaborative arrangement transactions                
Research and development           $ 4.1 $ 39.2 $ 89.1