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Indebtedness - Narrative (Details) - USD ($)
1 Months Ended 12 Months Ended
Sep. 26, 2023
Jul. 31, 2022
Feb. 28, 2021
Jan. 31, 2020
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Sep. 15, 2022
Apr. 30, 2020
Sep. 15, 2015
Debt Instrument                    
Interest rate on senior notes         3.625%          
Aggregate principal amount, debt converted   $ 2,400,000                
Senior notes aggregate principal amount                   $ 1,000,000,000
Interest expense         $ 246,900,000 $ 246,600,000 $ 253,600,000      
Redemption rate               99.92%    
Revolving Credit Facility                    
Debt Instrument                    
Senior unsecured revolving credit facility maximum borrowing capacity       $ 1,000,000,000            
Debt instrument, term       5 years            
Outstanding borrowings         $ 0          
2015 Senior Notes                    
Debt Instrument                    
Redemptions percentage of 2015 notes         100.00%          
Redemption percentage for change in control provision         101.00%          
5.200% Senior Notes due September 15, 2045 | Senior Notes                    
Debt Instrument                    
Aggregate principal amount, debt converted     $ 8,900,000              
Aggregate cash payments     12,100,000              
Loss on extinguishment of debt     3,200,000              
Cash payments on debt extinguishment, including accrued interest     13,800,000              
Interest expense     $ 6,100,000              
Senior Notes | 2020 Senior Notes                    
Debt Instrument                    
Senior notes aggregate principal amount                 $ 3,000,000,000  
Redemptions percentage of 2015 notes         100.00%          
Redemption percentage for change in control provision         101.00%          
Costs associated with the senior notes offerings         $ 24,400,000          
Senior Notes | 2.250% Senior Notes due May 1, 2030                    
Debt Instrument                    
Interest rate on senior notes         2.25%       2.25%  
Senior notes aggregate principal amount                 $ 1,500,000,000  
Redemption percentage par value of senior notes                 99.973%  
Senior Notes | 3.150% Senior Notes due May 1, 2050                    
Debt Instrument                    
Interest rate on senior notes         3.15%       3.15%  
Senior notes aggregate principal amount                 $ 1,500,000,000  
Redemption percentage par value of senior notes                 99.174%  
Senior Notes | 2015 Senior Notes                    
Debt Instrument                    
Costs associated with the senior notes offerings         $ 47,500,000          
Senior Notes | 4.050% Senior Notes due September 15, 2025                    
Debt Instrument                    
Interest rate on senior notes         4.05%          
Senior notes aggregate principal amount         $ 1,750,000,000          
Redemption percentage par value of senior notes         99.764%          
Senior Notes | 5.200% Senior Notes due September 15, 2045                    
Debt Instrument                    
Interest rate on senior notes     5.20%   5.20%          
Aggregate principal amount, debt converted     $ 624,600,000              
Senior notes aggregate principal amount         $ 1,120,000,000          
Aggregate cash payments     $ 151,800,000              
Redemption percentage par value of senior notes         99.294%          
Senior Notes | 3.250% Senior Notes due February 15, 2051                    
Debt Instrument                    
Interest rate on senior notes     3.25%   3.25%          
Senior notes aggregate principal amount     $ 700,700,000              
Line of Credit | 2023 Term Loan                    
Debt Instrument                    
Senior unsecured revolving credit facility maximum borrowing capacity $ 1,500,000,000       $ 650,000,000          
Unused borrowing capacity, amount 500,000,000                  
Line of Credit | 2023 Term Loan | Reata Pharmaceuticals, Inc                    
Debt Instrument                    
Proceeds from long-term lines of credit 1,000,000,000                  
Line of Credit | 2023 Term Loan | Floating Rate 364-Day Tranche                    
Debt Instrument                    
Senior unsecured revolving credit facility maximum borrowing capacity         150,000,000          
Repayments of short-term debt, maturing in more than three months 350,000,000                  
Line of Credit | 2023 Term Loan | 2023 Term loan three-year tranche                    
Debt Instrument                    
Senior unsecured revolving credit facility maximum borrowing capacity         $ 500,000,000          
Line of Credit | 2023 Term Loan | 2023 Term loan three-year tranche | Reata Pharmaceuticals, Inc                    
Debt Instrument                    
Proceeds from long-term lines of credit $ 500,000,000