Intangible Assets and Goodwill (Details) - USD ($) $ in Millions	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022	Sep. 26, 2023	Dec. 31, 2022
Intangible assets
Total intangible assets, gross	$ 13,137.8		$ 13,137.8			$ 7,479.3
Accumulated Amortization	(5,793.2)		(5,793.2)			(5,629.2)
Intangible assets, net	7,344.6		7,344.6			1,850.1
Amortization and impairment of acquired intangible assets	60.9	$ 56.5	164.0	$ 190.9
Expected future amortization expense, 2023 (remaining three months)	75.0		75.0
Expected future amortization expense, 2024	325.0		325.0
Expected future amortization expense, 2025	430.0		430.0
Expected future amortization expense, 2026	440.0		440.0
Expected future amortization expense, 2027	435.0		435.0
Expected future amortization expense, 2028	445.0		445.0
Completed technology
Intangible assets
Cost	11,053.8		11,053.8			7,415.3
Net	5,260.6		5,260.6			1,786.1
Accumulated Amortization	$ (5,793.2)		$ (5,793.2)			(5,629.2)
Completed technology | Minimum
Intangible assets
Useful life	4 years		4 years
Completed technology | Maximum
Intangible assets
Useful life	28 years		28 years
Completed technology for SKYCLARYS (U.S.) | Reata Pharmaceuticals, Inc
Intangible assets
Intangible assets:					$ 3,600.0
Trademarks and Trade Names
Intangible assets
Cost and Net	$ 64.0		$ 64.0			64.0
Indefinite-lived Intangible Assets (Excluding Goodwill)	64.0		64.0			64.0
In-process research and development
Intangible assets
Cost and Net	1,920.0		1,920.0			0.0
Indefinite-lived Intangible Assets (Excluding Goodwill)	1,920.0		1,920.0			$ 0.0
Priority review voucher
Intangible assets
Cost and Net	100.0		100.0
Indefinite-lived Intangible Assets (Excluding Goodwill)	$ 100.0		$ 100.0