Revenue - Other Revenues (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Disaggregation of Revenue [Line Items]
Total product revenue	$ 10,173.4	$ 10,981.7	$ 13,444.6
Royalty revenue
Disaggregation of Revenue [Line Items]
Total product revenue	67.4	48.6	55.5
Contract manufacturing and other revenue
Disaggregation of Revenue [Line Items]
Total product revenue	417.7	427.7	719.1
Total other revenue
Disaggregation of Revenue [Line Items]
Total product revenue	$ 485.1	$ 476.3	$ 774.6