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Collaborative and Other Relationships - Samsung Bioepis (Details)
₩ in Millions, $ in Millions
1 Months Ended 3 Months Ended 12 Months Ended
Apr. 30, 2022
USD ($)
Jan. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Nov. 30, 2018
USD ($)
Nov. 30, 2018
KRW (₩)
Aug. 31, 2017
USD ($)
May 31, 2016
USD ($)
Jan. 31, 2016
USD ($)
Dec. 31, 2013
USD ($)
Feb. 29, 2012
USD ($)
Sep. 30, 2021
USD ($)
Dec. 31, 2022
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
product
Mar. 31, 2022
KRW (₩)
Dec. 31, 2021
KRW (₩)
May 31, 2018
Feb. 29, 2012
KRW (₩)
Collaborative arrangements and non-collaborative arrangement transactions                                      
Income (loss) from equity method investments                       $ 2.6 $ 34.9 $ 3.3          
Income tax (benefit) expense                       632.8 52.5 992.3          
Number of ophthalmolgy biosimilar products | product                             2        
Research and development                       2,231.1 2,501.2 3,990.9          
Collaboration profit (loss) sharing                       (7.4) 7.2 232.9          
Revenue                       10,173.4 10,981.7 13,444.6          
Samsung Bioepis                                      
Collaborative arrangements and non-collaborative arrangement transactions                                      
Investment in Samsung Bioepis | ₩                               ₩ 581.6      
Proceeds from divestiture of interest in joint venture $ 1,000.0                                    
Due from joint venture 1,300.0                                    
Upfront and milestone payments made to collaborative partner   $ 100.0                                  
Research and development expense asset acquired                             $ 63.0        
Prepaid research and discovery services     $ 37.0                       $ 37.0        
Additional milestone payment 50.0                                    
Accrued milestone payment                     $ 15.0                
Estimated additional payments upon achievement of development and commercial milestones                       180.0              
Term of collaboration agreement                 10 years                    
Option exercise fee                       $ 60.0              
Research and development                 $ 46.0                    
Expected profit share percentage     45.00%                 50.00%              
Collaboration profit (loss) sharing                       $ 217.4 285.4 266.5          
Revenue                       $ 20.6 20.7 $ 20.9          
Term of collaboration agreement, additional length                 5 years     5 years              
Amounts receivable                       $ 2.0 4.1            
Amounts payable                       40.5 148.7            
Samsung Bioepis | Payment Due At First Anniversary                                      
Collaborative arrangements and non-collaborative arrangement transactions                                      
Due from joint venture 812.5                                    
Samsung Bioepis | Payment Due At Second Anniversary                                      
Collaborative arrangements and non-collaborative arrangement transactions                                      
Due from joint venture 437.5                                    
Samsung Bioepis | Development Milestones                                      
Collaborative arrangements and non-collaborative arrangement transactions                                      
Additional milestone payment                     $ 15.0                
Samsung Bioepis                                      
Collaborative arrangements and non-collaborative arrangement transactions                                      
Contributions by third party                   $ 250.0                 ₩ 280,500.0
Joint venture ownership percentage                   85.00%                  
Investment in Samsung Bioepis                   $ 45.0     599.9       ₩ 713,300.0   ₩ 49,500.0
Ownership percentage                   15.00%           49.90%     15.00%
Ownership percentage before additional purchase transaction                                   5.00%  
Payments to increase investment in Samsung Bioepis       $ 676.6 ₩ 759,500.0                            
Total basis difference $ 675.0                                    
Net profits on investment                       2.6 34.9            
Income (loss) from equity method investments                       17.0 64.6            
Amortization                       $ 14.4 29.7            
Income tax (benefit) expense                         $ 31.2            
Additional milestone payment                 $ 25.0                    
Net change in acquired and in-licensed rights and patents           $ 75.0 $ 75.0 $ 75.0                      
Samsung Bioepis | Inventories                                      
Collaborative arrangements and non-collaborative arrangement transactions                                      
Equity method investment basis difference amortization period 1 year 6 months                                    
Samsung Bioepis | Completed technology                                      
Collaborative arrangements and non-collaborative arrangement transactions                                      
Equity method investment basis difference amortization period 15 years