Collaborative and Other Relationships - Summary of Activity Related To Denali Therapeutics (Details) - Research and development - Denali Therapeutics - USD ($) $ in Millions	12 Months Ended
Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Collaborative arrangements and non-collaborative arrangement transactions
Expense incurred by the collaboration	$ 75.1	$ 42.5	$ 14.6
Expense reflected within statements of income	$ 43.8	$ 25.5	$ 8.8

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