Additional milestone payment.

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- Definition

Estimated additional payments upon achievement of development and commercial milestones.

+ References

No definition available.

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- Definition

Expected additional milestone payments when meeting certain sales threshold.

+ References

No definition available.

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- Definition

Expected license fee and regulatory milestone payments.

+ References

No definition available.

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- Definition

Investment In Common Stock, Shares Purchased

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No definition available.

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- Definition

License Fee

+ References

No definition available.

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- Definition

Percentage of royalties as per collaboration.

+ References

No definition available.

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- Definition

Purchase of common stock

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No definition available.

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- Definition

Term of collaboration agreement

+ References

No definition available.

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- Definition

Total payment to enter collaboration agreement

+ References

No definition available.

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- Definition

Total upfront and milestone payments made to collaborative partner.

+ References

No definition available.

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- Definition

Upfront Payment For Collaboration Agreement

+ References

No definition available.

+ Details

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

No definition available.

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- Definition

The aggregate costs related to goods produced and sold and services rendered by an entity during the reporting period. This excludes costs incurred during the reporting period related to financial services rendered and other revenue generating activities.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition

Amount of asset related to consideration paid in advance for costs that provide economic benefits in future periods, and amount of other assets.

+ References

No definition available.

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- Definition

The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

+ References

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- Definition

The costs incurred in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, excluding in-process research and development acquired in a business combination consummated during the period. Excludes software research and development, which has a separate concept.

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Collaborative and Other Relationships - Ionis (Details) - USD ($) shares in Millions, $ in Millions	1 Months Ended					12 Months Ended
	Dec. 31, 2019	Jun. 30, 2018	Dec. 31, 2017	Sep. 30, 2013	Dec. 31, 2012	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2016	Dec. 31, 2018
Collaborative arrangements and non-collaborative arrangement transactions
Cost of sales, excluding amortization and impairment of acquired intangible assets						$ 2,278.3	$ 2,109.7	$ 1,805.2
Research and development						2,231.1	2,501.2	3,990.9
Ionis Pharmaceuticals
Collaborative arrangements and non-collaborative arrangement transactions
License fee				$ 70.0	$ 70.0
Expected license fee and regulatory milestone payments				$ 130.0	$ 130.0
Research and development expense asset acquired	$ 45.0
Additional milestone payment	155.0
Term of collaboration agreement		10 years		6 years
Total payment to enter collaboration agreement		$ 1,000.0
Upfront payment for collaboration agreement		375.0
Purchase of common stock		$ 625.0
Investment in common stock, shares purchased (in shares)		11.5
Prepaid research and discovery services		$ 50.9
Research and development		324.1				10.0	22.5	11.3
Estimated additional payments upon achievement of development and commercial milestones			$ 260.0
Upfront and milestone payments made to collaborative partner			25.0
Expected additional milestone payments when certain sales threshold is met			$ 800.0
Ionis Pharmaceuticals \| SPINRAZA
Collaborative arrangements and non-collaborative arrangement transactions
Cost of sales, excluding amortization and impairment of acquired intangible assets						243.1	267.1	286.6
Ionis Pharmaceuticals \| BIIB115
Collaborative arrangements and non-collaborative arrangement transactions
Upfront payment for collaboration agreement							60.0
Ionis Pharmaceuticals \| SOD1
Collaborative arrangements and non-collaborative arrangement transactions
Research and development						$ 17.0	$ 10.0	$ 28.0
Estimated additional payments upon achievement of development and commercial milestones										$ 55.0
Ionis Pharmaceuticals \| BIIB080
Collaborative arrangements and non-collaborative arrangement transactions
Research and development expense asset acquired	$ 10.0
Ionis Pharmaceuticals \| Minimum
Collaborative arrangements and non-collaborative arrangement transactions
Estimated additional payments upon achievement of development and commercial milestones		125.0
Ionis Pharmaceuticals \| Minimum \| SPINRAZA
Collaborative arrangements and non-collaborative arrangement transactions
Percentage of royalties as per collaboration						11.00%			11.00%
Ionis Pharmaceuticals \| Maximum
Collaborative arrangements and non-collaborative arrangement transactions
Estimated additional payments upon achievement of development and commercial milestones		$ 270.0
Ionis Pharmaceuticals \| Maximum \| SPINRAZA
Collaborative arrangements and non-collaborative arrangement transactions
Percentage of royalties as per collaboration						15.00%			15.00%