Other Consolidated Financial Statement Detail - Narrative (Details) - USD ($) $ in Millions	12 Months Ended
Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Business Acquisition [Line Items]
Unrealized (gains) losses recognized on equity securities	$ 264.7	$ 831.4	$ (681.8)
Other long-term liabilities	944.2	1,320.5
Accrued income taxes	541.7	664.5
Denali, Ionis, Sage, and Sangamo
Business Acquisition [Line Items]
Unrealized (gains) losses recognized on equity securities	$ (278.0)	$ (819.6)

Carrying amount as of the balance sheet date of the unpaid sum of the known and estimated amounts payable to satisfy all domestic and foreign income tax obligations due beyond one year or the operating cycle, whichever is longer. Alternate captions include income taxes payable, noncurrent.

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