Revenues - Other Revenues (Details) - USD ($) $ in Millions	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Disaggregation of Revenue [Line Items]
Total revenue	$ 2,508.5	$ 2,778.9	$ 7,629.4	$ 8,247.9
Royalty
Disaggregation of Revenue [Line Items]
Total revenue	8.8	7.7	29.7	20.3
Other corporate revenues
Disaggregation of Revenue [Line Items]
Total revenue	114.2	143.8	242.9	314.1
Other
Disaggregation of Revenue [Line Items]
Total revenue	129.5	157.8	293.5	350.1
Collaborative arrangement | ZINBRYTA
Disaggregation of Revenue [Line Items]
Total revenue	$ 6.5	$ 6.3	$ 20.9	$ 15.7