Revenues - Other Revenues (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Disaggregation of Revenue [Line Items]
Total revenue	$ 2,589.1	$ 2,775.0	$ 5,120.9	$ 5,469.0
Royalty
Disaggregation of Revenue [Line Items]
Total revenue	10.3	6.4	20.9	12.6
Other corporate revenues
Disaggregation of Revenue [Line Items]
Total revenue	81.2	87.1	128.7	170.3
Other
Disaggregation of Revenue [Line Items]
Total revenue	97.9	99.0	164.0	192.3
Collaborative arrangement | ZINBRYTA
Disaggregation of Revenue [Line Items]
Total revenue	$ 6.4	$ 5.5	$ 14.4	$ 9.4