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Restructuring, Business Transformation and Other Cost Saving Initiatives
 3 Months Ended
Mar. 31, 2022
Restructuring and Related Activities [Abstract]  
Restructuring, Business Transformation and Other Cost Saving Initiatives RESTRUCTURING, BUSINESS TRANSFORMATION AND OTHER COST SAVING INITIATIVES
2022 Cost Saving Initiatives
In December 2021 and May 2022 we announced our plans to implement a series of cost-reduction measures during 2022. These savings are expected to be achieved through a number of initiatives, including reductions to our workforce, primarily within our global Alzheimer's infrastructure, the consolidation of certain real estate locations and operating efficiency gains across our selling, general and administrative and research and development functions.
Under these initiatives, we expect to incur restructuring charges ranging from approximately $100.0 million to $150.0 million. These amounts are primarily related to severance and are expected to be substantially incurred and paid by the end of 2022.
For the three months ended March 31, 2022, we recognized $27.7 million of employee related costs, primarily related to severance. These costs were recorded in restructuring charges in our condensed consolidated statements of income. Our restructuring reserve is included in accrued expense and other in our condensed consolidated balance sheets.
Following an evaluation of our current capacity needs, in March 2022 we ceased using a patient services office space in Durham, North Carolina. We are marketing the space for sublease. Our decision to cease using the facility resulted in the immediate expense of certain leasehold improvements and other assets at this facility, which we do not believe can be adequately recovered in a sublease. As a result, for the three months ended March 31, 2022, we recognized approximately $10.4 million of accelerated depreciation expense, which was recorded in restructuring charges in our condensed consolidated statements of income.
The following table summarizes the charges and spending related to our 2022 cost saving initiatives for the three months ended March 31, 2022:
(In millions)Workforce ReductionTotal
Restructuring reserve as of December 31, 2021$— $— 
Expense27.7 27.7 
Payment(6.2)(6.2)
Restructuring reserve as of March 31, 2022$21.5 $21.5