Income Taxes (Details)	3 Months Ended
Mar. 31, 2022	Mar. 31, 2021
Reconciliation between the U.S. federal statutory tax rate and effective tax rate
Statutory rate	21.00%	21.00%
State taxes	(0.40%)	0.80%
Taxes on foreign earnings	(10.80%)	(10.90%)
Credits and net operating loss utilization	(2.50%)	(3.70%)
Purchased intangible assets	0.60%	0.80%
GILTI	0.30%	0.90%
Neurimmune tax impacts	0.242	(0.006)
Other	3.80%	1.20%
Effective tax rate	36.20%	9.50%

Effective Tax Rate Reconciliation, GILTI tax

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Effective Tax Rate Reconciliation, NuerImmune Tax Impacts

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Percentage of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 12
-URI http://asc.fasb.org/extlink&oid=121826272&loc=d3e32687-109319

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Percentage of domestic federal statutory tax rate applicable to pretax income (loss).

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Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations applicable to statutory income tax expense (benefit) outside of the country of domicile.

+ References

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 12
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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations applicable to state and local income tax expense (benefit), net of federal tax expense (benefit).

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Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to tax credits. Including, but not limited to, research credit, foreign tax credit, investment tax credit, and other tax credits.

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