Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Cash flow from operating activities:
Net income	$ 218.5	$ 404.6
Adjustments to reconcile net income to net cash flow from operating activities:
Depreciation and amortization	143.1	102.6
Impairment of intangible assets	0.0	44.3
Excess and obsolescence charges related to inventory	281.5	11.9
Share-based compensation	67.6	70.0
Contingent consideration	(7.1)	(33.8)
Deferred income taxes	1.0	(15.0)
(Gain) loss on strategic investments	191.1	437.6
(Gain) loss on equity method investments	3.3	18.2
Other	43.3	59.8
Changes in operating assets and liabilities, net:
Accounts receivable	(87.5)	37.2
Due from anti-CD20 therapeutic programs	22.9	43.8
Inventory	(142.6)	(112.5)
Accrued expense and other current liabilities	(461.6)	(283.6)
Income tax assets and liabilities	101.9	64.8
Other changes in operating assets and liabilities, net	(213.6)	(80.9)
Net cash flow provided by (used in) operating activities	161.8	769.0
Cash flows from investing activities:
Purchases of property, plant and equipment	(57.9)	(92.6)
Proceeds from sales and maturities of marketable securities	543.6	819.2
Purchases of marketable securities	(1,133.5)	(913.3)
Proceeds from divestiture of Hillerød, Denmark manufacturing operations	0.0	28.1
Proceeds from the sales of strategic investments	0.0	(91.2)
Other	(0.2)	2.7
Net cash flow provided by (used in) investing activities	(648.0)	(64.7)
Cash flows from financing activities:
Purchases of treasury stock	0.0	(600.0)
Payments related to issuance of stock for share-based compensation arrangements, net	(20.8)	(27.1)
Repayment of borrowings and premiums paid on debt exchange	0.0	(169.3)
Net (distribution) contribution to noncontrolling interest	0.2	0.0
Other	4.1	11.4
Net cash flow provided by (used in) financing activities	(16.5)	(785.0)
Net increase (decrease) in cash and cash equivalents	(502.7)	(80.7)
Effect of exchange rate changes on cash and cash equivalents	(9.4)	(33.0)
Cash and cash equivalents, beginning of the period	2,261.4	1,331.2
Cash and cash equivalents, end of the period	$ 1,749.3	$ 1,217.5