Fair Value Measurements (Details Textual) - USD ($)	3 Months Ended
Mar. 31, 2022	Dec. 31, 2021
Business Acquisition, Contingent Consideration [Line Items]
Asset impairment charges	$ 0
Contingent consideration obligations	$ 202,000,000	$ 209,100,000
Technological and Regulatory Success, Probability	10.90%
3.625% Senior Notes due 2022
Business Acquisition, Contingent Consideration [Line Items]
Senior notes interest rate	3.625%
4.050% Senior Notes due 2025
Business Acquisition, Contingent Consideration [Line Items]
Senior notes interest rate	4.05%
5.200% Senior Notes due 2045
Business Acquisition, Contingent Consideration [Line Items]
Senior notes interest rate	5.20%

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Amount of liability recognized arising from contingent consideration in a business combination, expected to be settled beyond one year or the normal operating cycle, if longer.

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Contractual interest rate for funds borrowed, under the debt agreement.

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