Revenues - Other Revenues (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Disaggregation of Revenue [Line Items]
Total revenue	$ 2,531.8	$ 2,694.0
Royalty
Disaggregation of Revenue [Line Items]
Total revenue	10.6	6.2
Other corporate revenues
Disaggregation of Revenue [Line Items]
Total revenue	47.5	83.2
Other
Disaggregation of Revenue [Line Items]
Total revenue	66.1	93.3
Collaborative arrangement | ZINBRYTA
Disaggregation of Revenue [Line Items]
Total revenue	$ 8.0	$ 3.9