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Share-based Payments
3 Months Ended
Mar. 31, 2022
Share-based Payment Arrangement [Abstract]  
Share-based Payments
Share-based Compensation Expense
The following table summarizes share-based compensation expense included in our condensed consolidated statements of income:
For the Three Months Ended March 31,
(In millions)20222021
Research and development $25.7 $33.6 
Selling, general and administrative46.1 44.9 
Subtotal71.8 78.5 
Capitalized share-based compensation costs (2.8)(2.6)
Share-based compensation expense included in total cost and expense69.0 75.9 
Income tax effect(12.8)(14.0)
Share-based compensation expense included in net income attributable to Biogen Inc.$56.2 $61.9 
The following table summarizes share-based compensation expense associated with each of our share-based compensation programs:
For the Three Months Ended March 31,
(In millions)20222021
Market stock units$5.9 $16.5 
Time-vested restricted stock units51.3 42.8 
Performance stock units settled in stock8.3 6.3 
Performance stock units settled in cash1.4 6.0 
Employee stock purchase plan4.9 6.9 
Subtotal71.8 78.5 
Capitalized share-based compensation costs(2.8)(2.6)
Share-based compensation expense included in total cost and expense$69.0 $75.9 
We estimate the fair value of our obligations associated with our performance stock units settled in cash at the end of each reporting period through expected settlement. Cumulative adjustments to these obligations are recognized each quarter to reflect changes in the stock price and estimated outcome of the performance-related conditions.