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Fair Value Measurements
3 Months Ended
Mar. 31, 2022
Fair Value Disclosures [Abstract]  
Fair Value Measurements
The tables below present information about our assets and liabilities that are regularly measured and carried at fair value and indicate the level within the fair value hierarchy of the valuation techniques we utilized to determine such fair value:
As of March 31, 2022
(In millions)TotalQuoted Prices
in Active
Markets
(Level 1)
Significant Other
Observable Inputs
(Level 2)
Significant
Unobservable
Inputs
(Level 3)
Assets:
Cash equivalents$1,283.7 $— $1,283.7 $— 
Marketable debt securities:
Corporate debt securities1,579.4 — 1,579.4 — 
Government securities1,252.7 — 1,252.7 — 
Mortgage and other asset backed securities171.9 — 171.9 — 
Marketable equity securities860.3 607.0 253.3 — 
Derivative contracts97.2 — 97.2 — 
Plan assets for deferred compensation35.8 — 35.8 — 
Total$5,281.0 $607.0 $4,674.0 $— 
Liabilities:
Derivative contracts$12.5 $— $12.5 $— 
Contingent consideration obligations202.0 — — 202.0 
Total$214.5 $— $12.5 $202.0 
As of December 31, 2021
(In millions)TotalQuoted Prices
in Active
Markets
(Level 1)
Significant Other
Observable Inputs
(Level 2)
Significant
Unobservable
Inputs
(Level 3)
Assets:
Cash equivalents$1,632.2 $— $1,632.2 $— 
Marketable debt securities:
Corporate debt securities1,108.2 — 1,108.2 — 
Government securities1,192.7 — 1,192.7 — 
Mortgage and other asset backed securities132.2 — 132.2 — 
Marketable equity securities1,048.5 181.7 866.8 — 
Derivative contracts80.9 — 80.9 — 
Plan assets for deferred compensation33.4 — 33.4 — 
Total$5,228.1 $181.7 $5,046.4 $— 
Liabilities:
Derivative contracts$10.8 $— $10.8 $— 
Contingent consideration obligations209.1 — — 209.1 
Total$219.9 $— $10.8 $209.1 
There have been no material impairments of our assets measured and carried at fair value as of March 31, 2022 and December 31, 2021. In addition, there have been no changes in valuation techniques as of March 31, 2022 and December 31, 2021. The fair value of Level 2 instruments classified as cash equivalents and marketable debt securities was determined through third-party pricing services. The fair value of Level 2 instruments classified as marketable equity securities represents our investments in the common stock of Sangamo Therapeutics, Inc. (Sangamo) and Sage Therapeutics, Inc. (Sage) and are valued using an option pricing valuation model as the investments are each subject to certain holding period restrictions. The holding period restrictions for our investment in the common stock of Denali Therapeutics Inc. (Denali) and a portion of our Sangamo investment expired during the first quarter of 2022 and the second quarter of 2021, respectively. The fair value of our Denali investment and this portion of our Sangamo investment were Level 1 measurements as of March 31, 2022. For additional information on our investments in Sangamo, Denali and Sage common stock, please read Note 7, Financial Instruments, to these condensed consolidated financial statements.
For a description of our validation procedures related to prices provided by third-party pricing services and our option pricing valuation model, please read Note 1, Summary of Significant Accounting Policies - Fair Value Measurements, to our consolidated financial statements included in our 2021 Form 10-K.
The following tables summarize the significant unobservable inputs in the fair value measurement of our contingent consideration obligations as of March 31, 2022 and December 31, 2021:
As of March 31, 2022
(In millions)Fair ValueValuation TechniqueUnobservable Input(s)RangeWeighted Average
Liabilities:
Contingent consideration obligations$202.0 Discounted cash flowDiscount rate2.89%2.89%
Expected timing of achievement of development milestones2023 to 2027
As of December 31, 2021
(In millions)Fair ValueValuation TechniqueUnobservable Input(s)RangeWeighted Average
Liabilities:
Contingent consideration obligations$209.1 Discounted cash flowDiscount rate1.30%1.30%
Expected timing of achievement of development milestones2023 to 2027
The weighted average discount rate was calculated based on the relative fair value of our contingent consideration obligations. In addition, we apply various probabilities of technological and regulatory success, ranging from 10.9% to certain probability as of March 31, 2022, to the valuation models to estimate the fair values of our contingent consideration obligations.
Debt Instruments
The fair and carrying values of our debt instruments, which are Level 2 liabilities, are summarized as follows:
 As of March 31, 2022As of December 31, 2021
(In millions)Fair
Value
Carrying
Value
Fair
Value
Carrying
Value
3.625% Senior Notes due September 15, 2022$1,008.7 $999.5 $1,020.0 $999.1 
4.050% Senior Notes due September 15, 20251,797.6 1,743.4 1,895.2 1,742.9 
2.250% Senior Notes due May 1, 20301,341.6 1,492.2 1,475.9 1,492.0 
5.200% Senior Notes due September 15, 20451,240.0 1,100.0 1,463.0 1,099.9 
3.150% Senior Notes due May 1, 20501,225.3 1,473.3 1,457.7 1,473.2 
3.250% Senior Notes due February 15, 2051581.8 466.8 692.9 466.0 
Total$7,195.0 $7,275.2 $8,004.7 $7,273.1 
The fair values of each of our series of Senior Notes were determined through market, observable and corroborated sources. For additional information related to our Senior Notes, please read Note 12, Indebtedness, to our consolidated financial statements included in our 2021 Form 10-K.
Contingent Consideration Obligations
In connection with our acquisitions of Convergence and Biogen International Neuroscience GmbH, we agreed to make additional payments based upon the achievement of certain milestone events. The following table provides a roll forward of the fair values of our contingent consideration obligations, which includes Level 3 measurements:
 For the Three Months Ended March 31,
(In millions)20222021
Fair value, beginning of period$209.1 $259.8 
Changes in fair value(7.1)(33.8)
Fair value, end of period$202.0 $226.0 
As of March 31, 2022 and December 31, 2021, approximately $202.0 million and $209.1 million, respectively, of the fair value of our total contingent consideration obligations was reflected as a component of other long-term liabilities in our condensed consolidated balance sheets with any remaining balances reflected as a component of accrued expense and other.
For the three months ended March 31, 2022, changes in the fair value of our contingent consideration obligations were primarily due to an increase in discount rates used to revalue these obligations and delays in the expected timing of the achievement of certain remaining developmental milestones related to our vixotrigine programs.
For the three months ended March 31, 2021, changes in the fair value of our contingent consideration obligations were primarily due to delays in the expected timing of the achievement of certain remaining developmental milestones related to our vixotrigine programs.