Other Consolidated Financial Statement Detail (Tables)

12 Months Ended

Dec. 31, 2021

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Supplemental cash flow information

Supplemental disclosure of cash flow information for the years ended December 31, 2021, 2020 and 2019, is as follows:

	For the Years Ended December 31,
(In millions)	2021		2020		2019
Cash paid during the year for:
Interest	$	280.8	$	272.7	$	244.2
Income taxes	247.9		906.7		1,064.5

Other income (expense), net

Components of other income (expense), net, are summarized as follows:

	For the Years Ended December 31,
(In millions)	2021		2020		2019
Interest income	$	11.0	$	42.0	$	120.0
Interest expense	(253.6)		(222.5)		(187.4)
Gain (loss) on investments, net	(824.9)		685.7		204.7
Foreign exchange gains (losses), net	(22.4)		(10.7)		(7.0)
Other, net	(5.6)		2.9		(47.0)
Total other income (expense), net	$	(1,095.5)	$	497.4	$	83.3

Gain (loss) on investments

The following table summarizes our gain (loss) on investments, net that relates to our equity securities held as of December 31, 2021, 2020 and 2019:

	For the Years Ended December 31,
(In millions)	2021		2020		2019
Net gains (losses) recognized during the period on equity securities	$	(821.1)	$	693.9	$	200.1
Less: Net gains (losses) realized during the period and on equity securities	10.3		12.1		50.0
Unrealized gains (losses) recognized during the period on equity securities	$	(831.4)	$	681.8	$	150.1

Accrued expense and other

Accrued expense and other consists of the following:

	As of December 31,
(In millions)	2021		2020
Revenue-related reserves for discounts and allowances	$	802.1	$	1,080.6
Collaboration expense	324.7		389.9
Employee compensation and benefits	345.1		333.8
Royalties and licensing fees	234.7		218.5
Derivative liabilities	10.8		181.5
Current portion of contingent consideration obligations	—		149.6
Other	817.8		791.4
Total accrued expense and other	$	2,535.2	$	3,145.3