Segment Information - Geographic Information (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenue, Major Customer [Line Items]
Revenue	$ 10,981.7	$ 13,444.6	$ 14,377.9
Long-lived assets	3,791.8	3,844.8	3,674.3
U.S.
Revenue, Major Customer [Line Items]
Long-lived assets	1,390.5	1,496.3	1,493.2
Europe
Revenue, Major Customer [Line Items]
Long-lived assets	2,337.8	2,290.2	2,135.4
Germany
Revenue, Major Customer [Line Items]
Long-lived assets	25.4	31.2	27.5
Asia
Revenue, Major Customer [Line Items]
Long-lived assets	16.4	16.2	6.2
Other
Revenue, Major Customer [Line Items]
Long-lived assets	21.7	10.9	12.0
Product, net
Revenue, Major Customer [Line Items]
Revenue	8,846.9	10,692.2	11,379.8
Product, net | U.S.
Revenue, Major Customer [Line Items]
Revenue	3,805.7	5,900.1	6,713.8
Product, net | Europe
Revenue, Major Customer [Line Items]
Revenue	2,626.0	2,495.3	2,668.4
Product, net | Germany
Revenue, Major Customer [Line Items]
Revenue	1,162.4	1,161.1	1,126.1
Product, net | Asia
Revenue, Major Customer [Line Items]
Revenue	688.0	596.7	320.3
Product, net | Other
Revenue, Major Customer [Line Items]
Revenue	564.8	539.0	551.2
Revenue from anti-CD20 therapeutic programs
Revenue, Major Customer [Line Items]
Revenue	1,658.5	1,977.8	2,290.4
Revenue from anti-CD20 therapeutic programs | U.S.
Revenue, Major Customer [Line Items]
Revenue	1,596.7	1,897.4	2,211.9
Revenue from anti-CD20 therapeutic programs | Europe
Revenue, Major Customer [Line Items]
Revenue	0.0	0.1	0.2
Revenue from anti-CD20 therapeutic programs | Germany
Revenue, Major Customer [Line Items]
Revenue	0.0	0.0	0.0
Revenue from anti-CD20 therapeutic programs | Asia
Revenue, Major Customer [Line Items]
Revenue	0.0	0.0	0.0
Revenue from anti-CD20 therapeutic programs | Other
Revenue, Major Customer [Line Items]
Revenue	61.8	80.3	78.3
Other
Revenue, Major Customer [Line Items]
Revenue	476.3	774.6	707.7
Other | U.S.
Revenue, Major Customer [Line Items]
Revenue	429.9	733.6	585.8
Other | Europe
Revenue, Major Customer [Line Items]
Revenue	9.7	8.0	9.4
Other | Germany
Revenue, Major Customer [Line Items]
Revenue	0.0	0.1	0.3
Other | Asia
Revenue, Major Customer [Line Items]
Revenue	36.7	32.9	112.2
Other | Other
Revenue, Major Customer [Line Items]
Revenue	$ 0.0	$ 0.0	$ 0.0