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Other Consolidated Financial Statement Detail (Details) - USD ($)
$ in Millions
3 Months Ended 6 Months Ended
Jun. 30, 2019
Jun. 30, 2018
Jun. 30, 2019
Jun. 30, 2018
Dec. 31, 2018
Other Income (Expense), Net          
Interest income $ 29.1 $ 28.7 $ 60.3 $ 55.4  
Interest expense (47.7) (51.7) (95.6) (102.2)  
Gain (loss) on investments, net (173.4) 5.3 203.0 (9.1)  
Foreign exchange gains (losses), net 1.7 (13.0) (0.5) (14.0)  
Other, net (7.1) (3.8) (7.3) (5.6)  
Total other income (expense), net (197.4) (34.5) 159.9 (75.5)  
Equity Securities, FV-NI, Gain (Loss), Alternative [Abstract]          
Net gains (losses) recognized during the period on equity securities (174.2) 5.4 201.9 (1.5)  
Less: Net gains (losses) recognized during the period on equity securities sold during the period (42.9) 0.0 42.4 (0.5)  
Unrealized gains (losses) recognized during the period on equity securities held as of June 30, 2019 (131.3) $ 5.4 159.5 $ (1.0)  
Accrued Expenses and Other          
Revenue-related reserves for discounts and allowances 1,062.5   1,062.5   $ 1,051.3
Royalties and licensing fees 212.8   212.8   224.7
Employee compensation and benefits 199.4   199.4   320.9
Current portion of contingent consideration obligations 146.2   146.2   444.8
Collaboration expenses 130.4   130.4   261.6
Construction in progress 38.2   38.2   125.2
Other 727.5   727.5   609.3
Total accrued expenses and other 2,318.0   2,318.0   2,861.2
Component of accrued expenses and other          
Accrued Expenses and Other          
Revenue-related reserves for discounts and allowances $ 863.5   $ 863.5   $ 874.7