Intangible Assets and Goodwill (Tables)

6 Months Ended

Jun. 30, 2019

Goodwill and Intangible Assets Disclosure [Abstract]

Intangible assets, net of accumulated amortization, impairment charges and adjustments, are summarized as follows:



		As of June 30, 2019							As of December 31, 2018
(In millions)	Estimated Life	Cost		Accumulated Amortization			Net		Cost		Accumulated Amortization			Net
Out-licensed patents	13-23 years	$	543.3	$	(542.4	)	$	0.9	$	543.3	$	(542.3	)	$	1.0
Developed technology	15-23 years	3,005.3		(2,754.1		)	251.2		3,005.3		(2,734.8		)	270.5
In-process research and development	Indefinite until commercialization	1,175.6		—			1,175.6		476.0		—			476.0
Trademarks and tradenames	Indefinite	64.0		—			64.0		64.0		—			64.0
Acquired and in-licensed rights and patents	4-18 years	3,638.7		(1,449.1		)	2,189.6		3,638.7		(1,330.2		)	2,308.5
Total intangible assets		$	8,426.9	$	(4,745.6	)	$	3,681.3	$	7,727.3	$	(4,607.3	)	$	3,120.0

Estimated future amortization for acquired intangible assets

Based upon this most recent analysis, the estimated future amortization of acquired intangible assets for the next five years is expected to be as follows:



(In millions)	As of June 30, 2019
2019 (remaining six months)	$	130.0
2020	255.0
2021	215.0
2022	215.0
2023	220.0
2024	210.0

Summary of roll forward of the changes in goodwill

The following table provides a roll forward of the changes in our goodwill balance:



(In millions)	As of June 30, 2019
Goodwill, beginning of period	$	5,706.4
Increase to goodwill	112.6
Reclassification of goodwill to assets held for sale	(69.5		)
Other	(0.3		)
Goodwill, end of period	$	5,749.2