Intangible Assets and Goodwill (Tables)

3 Months Ended

Mar. 31, 2019

Goodwill and Intangible Assets Disclosure [Abstract]

Intangible assets, net of accumulated amortization, impairment charges and adjustments, are summarized as follows:



		As of March 31, 2019							As of December 31, 2018
(In millions)	Estimated Life	Cost		Accumulated Amortization			Net		Cost		Accumulated Amortization			Net
Out-licensed patents	13-23 years	$	543.3	$	(542.4	)	$	0.9	$	543.3	$	(542.3	)	$	1.0
Developed technology	15-23 years	3,005.3		(2,744.1		)	261.2		3,005.3		(2,734.8		)	270.5
In-process research and development	Indefinite until commercialization	480.5		—			480.5		476.0		—			476.0
Trademarks and tradenames	Indefinite	64.0		—			64.0		64.0		—			64.0
Acquired and in-licensed rights and patents	4-18 years	3,638.7		(1,389.1		)	2,249.6		3,638.7		(1,330.2		)	2,308.5
Total intangible assets		$	7,731.8	$	(4,675.6	)	$	3,056.2	$	7,727.3	$	(4,607.3	)	$	3,120.0

Estimated future amortization for acquired intangible assets

Based upon this most recent analysis, the estimated future amortization of acquired intangible assets for the next five years is expected to be as follows:



(In millions)	As of March 31, 2019
2019 (remaining nine months)	$	200.0
2020	290.0
2021	250.0
2022	250.0
2023	230.0
2024	190.0

Summary of roll forward of the changes in goodwill

The following table provides a roll forward of the changes in our goodwill balance:



(In millions)	As of March 31, 2019
Goodwill, beginning of period	$	5,706.4
Reclassification of goodwill to assets held for sale	(69.5		)
Other	2.8
Goodwill, end of period	$	5,639.7