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Financial Instruments (Details Textual 2)
shares in Millions, $ in Millions, ₩ in Billions
3 Months Ended 12 Months Ended
Dec. 31, 2018
USD ($)
Dec. 31, 2018
KRW (₩)
Jun. 30, 2018
Sep. 30, 2013
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2018
KRW (₩)
Jun. 05, 2018
USD ($)
shares
Dec. 31, 2012
USD ($)
Feb. 29, 2012
USD ($)
Feb. 29, 2012
KRW (₩)
Business Acquisition [Line Items]                        
Payments to Acquire Equity Method Investments         $ 676.6 $ 0.0 $ 0.0          
Strategic Investments                        
Business Acquisition [Line Items]                        
Strategic investment portfolio $ 676.3       $ 676.3 $ 85.8            
Ionis Pharmaceuticals                        
Business Acquisition [Line Items]                        
Term of collaboration agreement     10 years 6 years                
Total payment to enter collaboration agreement                 $ 1,000.0      
Upfront payment for collaboration agreement                 $ 375.0 $ 30.0    
Investment in common stock, shares purchased | shares                 11.5      
Purchase of common stock                 $ 625.0      
Samsung Bioepis                        
Business Acquisition [Line Items]                        
Equity Method Investment, Ownership Percentage Before Additional Purchase Transaction 5.00%       5.00%     5.00%        
Equity Method Investment, Ownership Percentage 49.90%       49.90%     49.90%     15.00% 15.00%
Payments to Acquire Equity Method Investments $ 676.6 ₩ 759.5                    
Equity Method Investments $ 680.6       $ 680.6     ₩ 759.5     $ 45.0 ₩ 49.5