Intangible Assets and Goodwill (Tables)

12 Months Ended

Dec. 31, 2018

Goodwill and Intangible Assets Disclosure [Abstract]

Intangible assets, net of accumulated amortization, impairment charges and adjustments are summarized as follows:



		As of December 31, 2018							As of December 31, 2017
(In millions)	Estimated Life	Cost		Accumulated Amortization			Net		Cost		Accumulated Amortization			Net
Out-licensed patents	13-23 years	$	543.3	$	(542.3	)	$	1.0	$	543.3	$	(535.6	)	$	7.7
Developed technology	15-23 years	3,005.3		(2,734.8		)	270.5		3,005.3		(2,689.0		)	316.3
In-process research and development	Indefinite until commercialization	476.0		—			476.0		680.6		—			680.6
Trademarks and trade names	Indefinite	64.0		—			64.0		64.0		—			64.0
Acquired and in-licensed rights and patents	4-18 years	3,638.7		(1,330.2		)	2,308.5		3,971.4		(1,160.4		)	2,811.0
Total intangible assets		$	7,727.3	$	(4,607.3	)	$	3,120.0	$	8,264.6	$	(4,385.0	)	$	3,879.6

Estimated future amortization of intangible assets

Based upon this most recent analysis, the estimated future amortization of acquired intangible assets for the next five years is expected to be as follows:



(In millions)	As of December 31, 2018
2019	$	270.0
2020	290.0
2021	250.0
2022	250.0
2023	230.0

Summary of roll forward of the changes in goodwill

The following table provides a roll forward of the changes in our goodwill balance:



	As of December 31,
(In millions)	2018			2017
Goodwill, beginning of year	$	4,632.5		$	3,669.3
Elimination of goodwill allocated to our hemophilia business	—			(314.1		)
Increase to goodwill	1,080.1			1,267.3
Other	(6.2		)	10.0
Goodwill, end of year	$	5,706.4		$	4,632.5