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Investments in Variable Interest Entities (Details) - USD ($)
$ in Millions
1 Months Ended 12 Months Ended
May 31, 2018
Oct. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Variable Interest Entity [Line Items]          
Payment to Neurimmune     $ 36.4 $ 134.1 $ 0.0
Investment in Variable Interest Entities (Textual)          
Investment in biotechnology companies that are determined to be unconsolidated variable interest entities     $ 28.7 $ 48.3  
Neurimmune          
Variable Interest Entity [Line Items]          
Payment to Neurimmune $ 50.0 $ 150.0      
Additional reduction in royalty rate payable on commercial sales 5.00%        
Reduction in royalty rate payable on commercial sales   15.00%