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Income Taxes (Details Textual) - USD ($)
$ in Millions
3 Months Ended 12 Months Ended
Dec. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Jan. 01, 2018
Tax Credit Carryforward [Line Items]          
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Percent   (1.90%) (11.10%) (9.60%)  
Statutory rate   21.00% 35.00% 35.00%  
Income tax benefit (expense)   $ 1,425.6 $ 2,458.7 $ 1,237.3  
Deferred tax liabilities, temporary differences, purchase accounting, foreign subsidiaries   1,500.0      
GILTI $ 0.0 (544.6) 0.0    
Net impairment on certain tax assets 48.8   48.8    
Income Taxes (Textual)          
Total deferred charges and prepaid taxes 617.7 239.2 617.7    
Unrecognized tax benefit 64.3 109.1 64.3 26.9  
Net interest expense   2.2 4.8 $ 9.1  
Unrecognized Tax Benefits, Interest on Income Taxes Accrued 16.1 $ 13.8 16.1    
2017 Tax Act          
Tax Credit Carryforward [Line Items]          
Statutory rate   21.00%      
Income tax benefit (expense)     1,173.6    
Transition toll tax liabilities 989.6 $ 697.0 989.6    
Payment for Transition Toll Tax   85.0      
Deferred tax liabilities, decrease due to overpayment   150.0      
Income tax expense (benefit) 184.0 12.7      
Reduction in deferred tax liability, undistributed foreign earnings   34.6      
GILTI   135.8      
Other tax expense (benefit)   11.0      
Foreign Tax Authority          
Tax Credit Carryforward [Line Items]          
Notice of assessment of corporate withholding tax including penalties and interest   60.0      
General Business | Domestic Country          
Tax Credit Carryforward [Line Items]          
Operating Loss Carryforwards   1.0      
Tax Credit Carryforward, Amount   1.3      
General Business | State and Local Jurisdiction          
Tax Credit Carryforward [Line Items]          
Deferred Tax Assets, Operating Loss Carryforwards, State and Local   4.6      
General Business | Foreign Tax Authority          
Tax Credit Carryforward [Line Items]          
Operating Loss Carryforwards   2,200.0      
Research | State and Local Jurisdiction          
Tax Credit Carryforward [Line Items]          
Tax Credit Carryforward, Amount   133.1      
Prepaid taxes          
Tax Credit Carryforward [Line Items]          
Net impairment on certain tax assets $ 142.6   $ 142.6    
Earnings in the form of cash and cash equivalents | 2017 Tax Act          
Tax Credit Carryforward [Line Items]          
Transition Toll Tax repatriation tax rate 15.50%   15.50%    
Other Foreign Earnings | 2017 Tax Act          
Tax Credit Carryforward [Line Items]          
Transition Toll Tax repatriation tax rate 8.00%   8.00%    
ZINBRYTA          
Tax Credit Carryforward [Line Items]          
Unrecorded tax benefit     $ 93.8    
Accounting Standards Update 2016-16 | Deferred tax liability          
Tax Credit Carryforward [Line Items]          
Cumulative effect of new accounting principle in period of adoption   400.0     $ 1,500.0
Accounting Standards Update 2016-16 | Retained Earnings          
Tax Credit Carryforward [Line Items]          
Cumulative effect of new accounting principle in period of adoption         500.0
Accounting Standards Update 2016-16 | Deferred Tax Asset          
Tax Credit Carryforward [Line Items]          
Cumulative effect of new accounting principle in period of adoption         $ 2,000.0
Minimum          
Tax Credit Carryforward [Line Items]          
Residual U.S. tax liability on reversal of deferred tax liabilities on foreign subsidiaries purchase accounting   300.0      
Maximum          
Tax Credit Carryforward [Line Items]          
Residual U.S. tax liability on reversal of deferred tax liabilities on foreign subsidiaries purchase accounting   $ 400.0      
Cost of Sales          
Tax Credit Carryforward [Line Items]          
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Percent   35000.00%