Intangible Assets and Goodwill (Tables)

9 Months Ended

Sep. 30, 2018

Goodwill and Intangible Assets Disclosure [Abstract]

Intangible assets

Intangible assets, net of accumulated amortization, impairment charges and adjustments, are summarized as follows:

		As of September 30, 2018							As of December 31, 2017
(In millions)	Estimated Life	Cost		Accumulated Amortization			Net		Cost		Accumulated Amortization			Net
Out-licensed patents	13-23 years	$	543.3	$	(541.6	)	$	1.7	$	543.3	$	(535.6	)	$	7.7
Developed  technology	15-23 years	3,005.3		(2,724.0		)	281.3		3,005.3		(2,689.0		)	316.3
In-process research and development	Indefinite until commercialization	480.9		—			480.9		680.6		—			680.6
Trademarks and  tradenames	Indefinite	64.0		—			64.0		64.0		—			64.0
Acquired and in-licensed rights  and patents	4-18 years	3,974.2		(1,423.1		)	2,551.1		3,971.4		(1,160.4		)	2,811.0
Total intangible assets		$	8,067.7	$	(4,688.7	)	$	3,379.0	$	8,264.6	$	(4,385.0	)	$	3,879.6

Estimated future amortization for acquired intangible assets

Based upon this analysis, the estimated future amortization of acquired intangible assets for the next five years is expected to be as follows:

(In millions)	As of September 30, 2018
2018 (remaining three months)	$	91.7
2019	367.0
2020	366.8
2021	249.4
2022	250.5
2023	230.0

Summary of roll forward of the changes in goodwill

The following table provides a roll forward of the changes in our goodwill balance:

(In millions)	As of September 30, 2018
Goodwill, beginning of period	$	4,632.5
Increase to goodwill	810.7
Other	(3.1		)
Goodwill, end of period	$	5,440.1