Intangible Assets and Goodwill (Tables)

6 Months Ended

Jun. 30, 2018

Goodwill and Intangible Assets Disclosure [Abstract]

Intangible assets

Intangible assets, net of accumulated amortization, impairment charges and adjustments, are summarized as follows:

		As of June 30, 2018							As of December 31, 2017
(In millions)	Estimated Life	Cost		Accumulated Amortization			Net		Cost		Accumulated Amortization			Net
Out-licensed patents	13-23 years	$	543.3	$	(539.9	)	$	3.4	$	543.3	$	(535.6	)	$	7.7
Developed  technology	15-23 years	3,005.3		(2,713.1		)	292.2		3,005.3		(2,689.0		)	316.3
In-process research and development	Indefinite until commercialization	670.5		—			670.5		680.6		—			680.6
Trademarks and  tradenames	Indefinite	64.0		—			64.0		64.0		—			64.0
Acquired and in-licensed rights  and patents	4-18 years	3,974.2		(1,343.0		)	2,631.2		3,971.4		(1,160.4		)	2,811.0
Total intangible assets		$	8,257.3	$	(4,596.0	)	$	3,661.3	$	8,264.6	$	(4,385.0	)	$	3,879.6

Estimated future amortization for acquired intangible assets

Based upon this analysis, the estimated future amortization of acquired intangible assets for the next five years is expected to be as follows:

(In millions)	As of June 30, 2018
2018 (remaining six months)	$	215.8
2019	402.6
2020	380.9
2021	255.0
2022	242.3
2023	211.2

Summary of roll forward of the changes in goodwill

The following table provides a roll forward of the changes in our goodwill balance:

(In millions)	As of June 30, 2018
Goodwill, beginning of period	$	4,632.5
Increase to goodwill	540.9
Other	(3.1		)
Goodwill, end of period	$	5,170.3