Intangible Assets and Goodwill (Tables)

3 Months Ended

Mar. 31, 2018

Goodwill and Intangible Assets Disclosure [Abstract]

Intangible assets

Intangible assets, net of accumulated amortization, impairment charges and adjustments, are summarized as follows:

		As of March 31, 2018							As of December 31, 2017
(In millions)	Estimated Life	Cost		Accumulated Amortization			Net		Cost		Accumulated Amortization			Net
Out-licensed patents	13-23 years	$	543.3	$	(537.8	)	$	5.5	$	543.3	$	(535.6	)	$	7.7
Developed  technology	15-23 years	3,005.3		(2,700.5		)	304.8		3,005.3		(2,689.0		)	316.3
In-process research and development	Indefinite until commercialization	696.4		—			696.4		680.6		—			680.6
Trademarks and  tradenames	Indefinite	64.0		—			64.0		64.0		—			64.0
Acquired and in-licensed rights  and patents	4-18 years	3,974.7		(1,250.9		)	2,723.8		3,971.4		(1,160.4		)	2,811.0
Total intangible assets		$	8,283.7	$	(4,489.2	)	$	3,794.5	$	8,264.6	$	(4,385.0	)	$	3,879.6

Estimated future amortization for acquired intangible assets

Based upon this analysis, the estimated future amortization of acquired intangible assets for the next five years is expected to be as follows:

(In millions)	As of March 31, 2018
2018 (remaining nine months)	$	330.7
2019	402.6
2020	379.5
2021	255.0
2022	242.2
2023	211.2

Summary of roll forward of the changes in goodwill

The following table provides a roll forward of the changes in our goodwill balance:

(In millions)	As of March 31, 2018
Goodwill, beginning of period	$	4,632.5
Increase to goodwill	270.5
Other	4.8
Goodwill, end of period	$	4,907.8