Intangible Assets and Goodwill (Tables)

12 Months Ended

Dec. 31, 2017

Goodwill and Intangible Assets Disclosure [Abstract]

Intangible assets

Intangible assets, net of accumulated amortization, impairment charges and adjustments are summarized as follows:

		As of December 31, 2017							As of December 31, 2016
(In millions)	Estimated Life	Cost		Accumulated Amortization			Net		Cost		Accumulated Amortization			Net
Out-licensed patents	13-23 years	$	543.3	$	(535.6	)	$	7.7	$	543.3	$	(523.6	)	$	19.7
Developed technology	15-23 years	3,005.3		(2,689.0		)	316.3		3,005.3		(2,634.3		)	371.0
In-process research and development	Indefinite until commercialization	680.6		—			680.6		648.0		—			648.0
Trademarks and trade names	Indefinite	64.0		—			64.0		64.0		—			64.0
Acquired and in-licensed rights and patents	4-18 years	3,971.4		(1,160.4		)	2,811.0		3,481.7		(776.1		)	2,705.6
Total intangible assets		$	8,264.6	$	(4,385.0	)	$	3,879.6	$	7,742.3	$	(3,934.0	)	$	3,808.3

Estimated future amortization of intangible assets

Based upon this analysis, the estimated future amortization of acquired intangible assets for the next five years is expected to be as follows:

(In millions)	As of December 31, 2017
2018	$	423.5
2019	401.8
2020	381.6
2021	254.3
2022	242.3

Summary of roll forward of the changes in goodwill

The following table provides a roll forward of the changes in our goodwill balance:

	As of December 31,
(In millions)	2017			2016
Goodwill, beginning of year	$	3,669.3		$	2,663.8
Elimination of goodwill allocated to our hemophilia business	(314.1		)	—
Increase to goodwill	1,267.3			1,026.9
Other	10.0			(21.4		)
Goodwill, end of year	$	4,632.5		$	3,669.3