Intangible Assets and Goodwill (Tables)

9 Months Ended

Sep. 30, 2017

Goodwill and Intangible Assets Disclosure [Abstract]

Intangible assets

Intangible assets, net of accumulated amortization, impairment charges and adjustments, are summarized as follows:

		As of September 30, 2017							As of December 31, 2016
(In millions)	Estimated Life	Cost		Accumulated Amortization			Net		Cost		Accumulated Amortization			Net
Out-licensed patents	13-23 years	$	543.3	$	(532.7	)	$	10.6	$	543.3	$	(523.6	)	$	19.7
Developed  technology	15-23 years	3,005.3		(2,675.8		)	329.5		3,005.3		(2,634.3		)	371.0
In-process research and development	Indefinite until commercialization	680.6		—			680.6		648.0		—			648.0
Trademarks and  tradenames	Indefinite	64.0		—			64.0		64.0		—			64.0
Acquired and in-licensed rights  and patents	4-18 years	4,002.6		(1,067.9		)	2,934.7		3,481.7		(776.1		)	2,705.6
Total intangible assets		$	8,295.8	$	(4,276.4	)	$	4,019.4	$	7,742.3	$	(3,934.0	)	$	3,808.3

Estimated future amortization for acquired intangible assets

Based upon the above, the estimated future amortization of acquired intangible assets is expected to be as follows:

(In millions)	As of September 30, 2017
2017 (remaining three months)	$	106.8
2018	421.3
2019	404.0
2020	389.6
2021	256.6
2022	244.7

Summary of roll forward of the changes in goodwill

The following table provides a roll forward of the changes in our goodwill balance:

(In millions)	As of September 30, 2017
Goodwill, beginning of period	$	3,669.3
Elimination of goodwill allocated to our hemophilia business	(314.1		)
Increase to goodwill	762.4
Other	9.9
Goodwill, end of period	$	4,127.5