Intangible Assets and Goodwill (Tables)

6 Months Ended

Jun. 30, 2017

Goodwill and Intangible Assets Disclosure [Abstract]

Intangible assets

Intangible assets, net of accumulated amortization, impairment charges and adjustments, are summarized as follows:

		As of June 30, 2017							As of December 31, 2016
(In millions)	Estimated Life	Cost		Accumulated Amortization			Net		Cost		Accumulated Amortization			Net
Out-licensed patents	13-23 years	$	543.3	$	(529.8	)	$	13.5	$	543.3	$	(523.6	)	$	19.7
Developed  technology	15-23 years	3,005.3		(2,662.2		)	343.1		3,005.3		(2,634.3		)	371.0
In-process research and development	Indefinite until commercialization	668.6		—			668.6		648.0		—			648.0
Trademarks and  tradenames	Indefinite	64.0		—			64.0		64.0		—			64.0
Acquired and in-licensed rights  and patents	4-18 years	3,937.1		(975.0		)	2,962.1		3,481.7		(776.1		)	2,705.6
Total intangible assets		$	8,218.3	$	(4,167.0	)	$	4,051.3	$	7,742.3	$	(3,934.0	)	$	3,808.3

Estimated future amortization for acquired intangible assets

Based upon the above, the estimated future amortization of acquired intangible assets is expected to be as follows:

(In millions)	As of June 30, 2017
2017 (remaining six months)	$	222.6
2018	425.8
2019	412.5
2020	378.6
2021	239.3
2022	216.7

Summary of roll forward of the changes in goodwill

The following table provides a roll forward of the changes in our goodwill balance:

(In millions)	As of June 30, 2017
Goodwill, beginning of period	$	3,669.3
Elimination of goodwill allocated to our hemophilia business	(314.1		)
Increase to goodwill	508.9
Other	6.3
Goodwill, end of period	$	3,870.4