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Investments in Variable Interest Entities (Details) - USD ($)
$ in Millions
3 Months Ended
Mar. 31, 2017
Dec. 31, 2016
Variable Interest Entity [Line Items]    
Investment in biotechnology companies that are determined to be unconsolidated variable interest entities $ 53.5 $ 47.4
Neurimmune    
Variable Interest Entity [Line Items]    
Research and development cost in support of collaboration agreement 100.00%