Intangible Assets and Goodwill (Tables)

3 Months Ended

Mar. 31, 2017

Goodwill and Intangible Assets Disclosure [Abstract]

Intangible assets

Intangible assets, net of accumulated amortization, impairment charges and adjustments, are summarized as follows:

		As of March 31, 2017							As of December 31, 2016
(In millions)	Estimated Life	Cost		Accumulated Amortization			Net		Cost		Accumulated Amortization			Net
Out-licensed patents	13-23 years	$	543.3	$	(526.6	)	$	16.7	$	543.3	$	(523.6	)	$	19.7
Developed  technology	15-23 years	3,005.3		(2,648.1		)	357.2		3,005.3		(2,634.3		)	371.0
In-process research and development	Indefinite until commercialization	653.7		—			653.7		648.0		—			648.0
Trademarks and  tradenames	Indefinite	64.0		—			64.0		64.0		—			64.0
Acquired and in-licensed rights  and patents	4-18 years	3,887.1		(874.8		)	3,012.3		3,481.7		(776.1		)	2,705.6
Total intangible assets		$	8,153.4	$	(4,049.5	)	$	4,103.9	$	7,742.3	$	(3,934.0	)	$	3,808.3

Estimated future amortization for acquired intangible assets

Based upon the above, the estimated future amortization of acquired intangible assets is expected to be as follows:

(In millions)	As of March 31, 2017
2017 (remaining nine months)	$	346.5
2018	425.5
2019	412.4
2020	378.5
2021	239.2
2022	216.7

Summary of roll forward of the changes in goodwill

The following table provides a roll forward of the changes in our goodwill balance:

(In millions)	As of March 31, 2017
Goodwill, beginning of period	$	3,669.3
Elimination of goodwill allocated to our hemophilia business	(314.1		)
Increase to goodwill	254.7
Other	1.8
Goodwill, end of period	$	3,611.7