Inventory (Details Textual) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Inventory [Line Items]
Write-downs on excess, obsolete, unmarketable or other inventory	$ 48.2	$ 41.9	$ 50.6
ZINBRYTA
Inventory [Line Items]
Pre-approval inventory		24.7
FLIXABI
Inventory [Line Items]
Pre-approval inventory		24.2
BENEPALI
Inventory [Line Items]
Pre-approval inventory		$ 18.4