Consolidated Statements of Cash Flows - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Cash flows from operating activities:
Net income	$ 3,695.7	$ 3,593.2	$ 2,941.6
Adjustments to reconcile net income to net cash flows from operating activities:
Depreciation and amortization	682.7	600.4	688.1
Share-based compensation	154.8	161.4	155.3
Deferred income taxes	(175.0)	(145.6)	(308.2)
Other	91.2	82.2	(50.3)
Changes in operating assets and liabilities, net:
Accounts receivable	(241.4)	29.0	(512.4)
Due from anti-CD20 therapeutic programs	13.9	(31.1)	(30.7)
Inventory	(165.6)	(174.4)	(185.9)
Other assets	59.1	(127.0)	(108.7)
Accrued expenses and other current liabilities	570.1	74.2	244.3
Income tax assets and liabilities	(232.6)	(429.4)	40.3
Other liabilities	69.5	83.2	68.7
Net cash flows provided by operating activities	4,522.4	3,716.1	2,942.1
Cash flows from investing activities:
Proceeds from sales and maturities of marketable securities	7,378.9	4,063.0	2,718.9
Purchases of marketable securities	(7,913.2)	(6,864.9)	(3,583.1)
Contingent consideration related to Fumapharm AG acquisition	(1,200.0)	(850.0)	(375.0)
Acquisitions of businesses, net of cash acquired	0.0	(198.8)	0.0
Purchases of property, plant and equipment	(616.1)	(643.0)	(287.8)
Acquisitions of intangible assets	(111.6)	(15.4)	(28.2)
Other	(22.8)	(44.5)	12.2
Net cash flows used in investing activities	(2,484.8)	(4,553.6)	(1,543.0)
Cash flows from financing activities:
Purchases of treasury stock	(1,000.0)	(5,000.0)	(886.8)
Proceeds from issuance of stock for share-based compensation arrangements	43.7	54.2	54.9
Proceeds from borrowings	0.0	5,930.5	0.0
Repayments of borrowings	(2.7)	(2.1)	(2.7)
Excess tax benefit from share-based compensation	12.6	78.2	96.4
Contingent consideration payments	(38.6)	(13.1)	(20.5)
Other	(2.8)	(61.3)	2.8
Net cash flows provided by (used in) financing activities	(987.8)	986.4	(755.9)
Net increase in cash and cash equivalents	1,049.8	148.9	643.2
Effect of exchange rate changes on cash and cash equivalents	(31.3)	(45.8)	(40.9)
Cash and cash equivalents, beginning of the year	1,308.0	1,204.9	602.6
Cash and cash equivalents, end of the year	$ 2,326.5	$ 1,308.0	$ 1,204.9