Intangible Assets and Goodwill (Tables)

12 Months Ended

Dec. 31, 2016

Goodwill and Intangible Assets Disclosure [Abstract]

Intangible assets

		As of December 31, 2016							As of December 31, 2015
(In millions)	Estimated Life	Cost		Accumulated Amortization			Net		Cost		Accumulated Amortization			Net
Out-licensed patents	13-23 years	$	543.3	$	(523.6	)	$	19.7	$	543.3	$	(506.0	)	$	37.3
Developed technology	15-23 years	3,005.3		(2,634.3		)	371.0		3,005.3		(2,552.9		)	452.4
In-process research and development	Indefinite until commercialization	648.0		—			648.0		730.5		—			730.5
Trademarks and trade names	Indefinite	64.0		—			64.0		64.0		—			64.0
Acquired and in-licensed rights and patents	6-18 years	3,481.7		(776.1		)	2,705.6		3,303.2		(502.3		)	2,800.9
Total intangible assets		$	7,742.3	$	(3,934.0	)	$	3,808.3	$	7,646.3	$	(3,561.2	)	$	4,085.1

Estimated future amortization of intangible assets

(In millions)	As of December 31, 2016
2017	$	334.8
2018	312.7
2019	295.2
2020	259.7
2021	242.8

Summary of roll forward of the changes in goodwill

	As of December 31,
(In millions)	2016			2015
Goodwill, beginning of year	$	2,663.8		$	1,760.2
Increase to goodwill	1,026.9			908.1
Other	(21.4		)	(4.5		)
Goodwill, end of year	$	3,669.3		$	2,663.8