Intangible Assets and Goodwill (Tables)

9 Months Ended

Sep. 30, 2016

Goodwill and Intangible Assets Disclosure [Abstract]

Intangible assets

Intangible assets, net of accumulated amortization, impairment charges and adjustments, are summarized as follows:

		As of September 30, 2016							As of December 31, 2015
(In millions)	Estimated Life	Cost		Accumulated Amortization			Net		Cost		Accumulated Amortization			Net
Out-licensed patents	13-23 years	$	543.3	$	(519.4	)	$	23.9	$	543.3	$	(506.0	)	$	37.3
Developed  technology	15-23 years	3,005.3		(2,619.8		)	385.5		3,005.3		(2,552.9		)	452.4
In-process research and development	Indefinite until commercialization	679.7		—			679.7		730.5		—			730.5
Trademarks and  tradenames	Indefinite	64.0		—			64.0		64.0		—			64.0
Acquired and in-licensed rights  and patents	6-18 years	3,420.2		(703.4		)	2,716.8		3,303.2		(502.3		)	2,800.9
Total intangible assets		$	7,712.5	$	(3,842.6	)	$	3,869.9	$	7,646.3	$	(3,561.2	)	$	4,085.1

Estimated future amortization for acquired intangible assets

Based upon this analysis, the estimated future amortization of acquired intangible assets for the next five years is expected to be as follows:

(In millions)	As of September 30, 2016
2016 (remaining three months)	$	92.8
2017	347.8
2018	321.4
2019	301.9
2020	265.6
2021	247.7

Summary of roll forward of the changes in goodwill

The following table provides a roll forward of the changes in our goodwill balance:

(In millions)	As of September 30, 2016
Goodwill, beginning of period	$	2,663.8
Increase to goodwill	771.3
Other	(15.4		)
Goodwill, end of period	$	3,419.7