Intangible Assets and Goodwill (Tables)

6 Months Ended

Jun. 30, 2016

Goodwill and Intangible Assets Disclosure [Abstract]

Intangible assets

Intangible assets, net of accumulated amortization, impairment charges and adjustments, are summarized as follows:

		As of June 30, 2016							As of December 31, 2015
(In millions)	Estimated Life	Cost		Accumulated Amortization			Net		Cost		Accumulated Amortization			Net
Out-licensed patents	13-23 years	$	543.3	$	(514.9	)	$	28.4	$	543.3	$	(506.0	)	$	37.3
Developed  technology	15-23 years	3,005.3		(2,604.5		)	400.8		3,005.3		(2,552.9		)	452.4
In-process research and development	Indefinite until commercialization	692.3		—			692.3		730.5		—			730.5
Trademarks and  tradenames	Indefinite	64.0		—			64.0		64.0		—			64.0
Acquired and in-licensed rights  and patents	6-18 years	3,405.4		(623.3		)	2,782.1		3,303.2		(502.3		)	2,800.9
Total intangible assets		$	7,710.3	$	(3,742.7	)	$	3,967.6	$	7,646.3	$	(3,561.2	)	$	4,085.1

Estimated future amortization for acquired intangible assets

Based upon this analysis, the estimated future amortization of acquired intangible assets for the next five years is expected to be as follows:

(In millions)	As of June 30, 2016
2016 (remaining six months)	$	181.6
2017	325.1
2018	298.2
2019	282.7
2020	277.1
2021	265.0

Summary of roll forward of the changes in goodwill

The following table provides a roll forward of the changes in our goodwill balance:

(In millions)	As of June 30, 2016
Goodwill, beginning of period	$	2,663.8
Increase to goodwill	515.0
Other	(11.7		)
Goodwill, end of period	$	3,167.1