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Intangible Assets and Goodwill
6 Months Ended
Jun. 30, 2016
Goodwill and Intangible Assets Disclosure [Abstract]  
Intangible Assets and Goodwill
Intangible Assets and Goodwill
Intangible Assets
Intangible assets, net of accumulated amortization, impairment charges and adjustments, are summarized as follows:
 
 
 
As of June 30, 2016
 
As of December 31, 2015
(In millions)
Estimated
Life
 
Cost
 
Accumulated
Amortization
 
Net
 
Cost
 
Accumulated
Amortization
 
Net
Out-licensed patents
13-23 years
 
$
543.3

 
$
(514.9
)
 
$
28.4

 
$
543.3

 
$
(506.0
)
 
$
37.3

Developed 
technology
15-23 years
 
3,005.3

 
(2,604.5
)
 
400.8

 
3,005.3

 
(2,552.9
)
 
452.4

In-process research and development
Indefinite until commercialization
 
692.3

 

 
692.3

 
730.5

 

 
730.5

Trademarks and 
tradenames
Indefinite
 
64.0

 

 
64.0

 
64.0

 

 
64.0

Acquired and in-licensed rights 
and patents
6-18 years
 
3,405.4

 
(623.3
)
 
2,782.1

 
3,303.2

 
(502.3
)
 
2,800.9

Total intangible assets
 
 
$
7,710.3

 
$
(3,742.7
)
 
$
3,967.6

 
$
7,646.3

 
$
(3,561.2
)
 
$
4,085.1


For the three and six months ended June 30, 2016, amortization of acquired intangible assets totaled $92.9 million and $181.7 million, respectively, as compared to $92.0 million and $187.9 million, respectively, in the prior year comparative periods. In-process research and development amounts include adjustments for foreign exchange rate fluctuations.
Developed Technology
Developed technology primarily relates to our AVONEX product, which was recorded in connection with the merger of Biogen, Inc. and IDEC Pharmaceuticals Corporation in 2003. The net book value of this asset as of June 30, 2016 was $392.8 million.
Acquired and In-licensed Rights and Patents
Acquired and in-licensed rights and patents primarily relate to our acquisition of all remaining rights to TYSABRI from Elan Corporation plc (Elan). The net book value of this asset as of June 30, 2016 was $2,633.4 million.
The increase in acquired and in-licensed rights and patents during the six months ended June 30, 2016, primarily reflects:
$50.0 million in total milestone payments due to Samsung Bioepis, which became payable upon the approval of BENEPALI and FLIXABI in the E.U. in January 2016 and May 2016, respectively;
$20.0 million milestone payment due to AbbVie Biotherapeutics, Inc. (AbbVie), which became payable upon the regulatory approval of ZINBRYTA in the U.S. in May 2016; and
$26.5 million upon the approval of ALPROLIX in the E.U. in May 2016, which is comprised of a $20.0 million contingent payment due to the former owners of Syntonix Pharmaceuticals, Inc. (Syntonix) and $6.5 million related to the establishment of a corresponding deferred tax liability.
For additional information on our relationship with Samsung Bioepis, please read Note 17, Collaborative and Other Relationships to these condensed consolidated financial statements. For additional information on our relationship with Syntonix, please read Note 21, Commitments and Contingencies to our consolidated financial statements included in our 2015 Form 10-K. For additional information on our relationship with AbbVie, please read Note 19, Collaborative and Other Relationships to our consolidated financial statements included in our 2015 Form 10-K.
Estimated Future Amortization of Intangible Assets
Our amortization expense is based on the economic consumption of intangible assets. Our most significant intangible assets are related to our AVONEX and TYSABRI products. Annually, during our long-range planning cycle, we perform an analysis of anticipated lifetime revenues of AVONEX and TYSABRI. This analysis is also updated whenever events or changes in circumstances would significantly affect the anticipated lifetime revenues of either product.
Our most recent long range planning cycle was completed in the third quarter of 2015. Based upon this analysis, the estimated future amortization of acquired intangible assets for the next five years is expected to be as follows:
(In millions)
As of
June 30,
2016
2016 (remaining six months)
$
181.6

2017
325.1

2018
298.2

2019
282.7

2020
277.1

2021
265.0


Goodwill
The following table provides a roll forward of the changes in our goodwill balance:
(In millions)
As of
June 30,
2016
Goodwill, beginning of period
$
2,663.8

Increase to goodwill
515.0

Other
(11.7
)
Goodwill, end of period
$
3,167.1


The increase in goodwill during the six months ended June 30, 2016 was related to $600.0 million in contingent milestones achieved (exclusive of $85.0 million in tax benefits) and payable to the former shareholders of Fumapharm AG or holders of their rights. Other includes changes in foreign exchange rates. For additional information related to future contingent payments to the former shareholders of Fumapharm AG or holders of their rights, please read Note 19, Commitments and Contingencies to these condensed consolidated financial statements.
As of June 30, 2016, we had no accumulated impairment losses related to goodwill.