Intangible Assets and Goodwill (Tables)

3 Months Ended

Mar. 31, 2016

Goodwill and Intangible Assets Disclosure [Abstract]

Intangible assets

Intangible assets, net of accumulated amortization, impairment charges and adjustments, are summarized as follows:

		As of March 31, 2016							As of December 31, 2015
(In millions)	Estimated Life	Cost		Accumulated Amortization			Net		Cost		Accumulated Amortization			Net
Out-licensed patents	13-23 years	$	543.3	$	(510.5	)	$	32.8	$	543.3	$	(506.0	)	$	37.3
Developed  technology	15-23 years	3,005.3		(2,578.1		)	427.2		3,005.3		(2,552.9		)	452.4
In-process research and development	Indefinite until commercialization	718.5		—			718.5		730.5		—			730.5
Trademarks and  tradenames	Indefinite	64.0		—			64.0		64.0		—			64.0
Acquired and in-licensed rights  and patents	6-18 years	3,331.1		(561.4		)	2,769.7		3,303.2		(502.3		)	2,800.9
Total intangible assets		$	7,662.2	$	(3,650.0	)	$	4,012.2	$	7,646.3	$	(3,561.2	)	$	4,085.1

Estimated future amortization for acquired intangible assets

Based upon this analysis, the estimated future amortization of acquired intangible assets is expected to be as follows:

(In millions)	As of March 31, 2016
2016 (remaining nine months)	$	265.3
2017	321.0
2018	293.6
2019	277.6
2020	271.6
2021	259.3
Total	$	1,688.4

Summary of roll forward of the changes in goodwill

The following table provides a roll forward of the changes in our goodwill balance:

(In millions)	As of March 31, 2016
Goodwill, beginning of year	$	2,663.8
Increase to goodwill	257.8
Other	(3.7		)
Goodwill, end of year	$	2,917.9