Consolidated Statements of Cash Flows - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Cash flows from operating activities:
Net income	$ 3,593.2	$ 2,941.6	$ 1,862.3
Adjustments to reconcile net income to net cash flows from operating activities:
Depreciation and amortization	600.4	688.1	531.7
Share-based compensation	161.4	155.3	136.3
Deferred income taxes	(145.6)	(308.2)	(245.1)
Other	82.2	(50.3)	(27.6)
Changes in operating assets and liabilities, net:
Accounts receivable	29.0	(512.4)	(126.7)
Inventory	(174.4)	(185.9)	(243.9)
Other assets	(156.6)	(94.5)	(160.2)
Accrued expenses and other current liabilities	74.2	244.3	284.1
Current taxes payable	(410.2)	61.0	156.8
Other long-term liabilities and taxes payable	93.6	33.8	161.7
Due from unconsolidated joint business	(31.1)	(30.7)	15.7
Net cash flows provided by operating activities	3,716.1	2,942.1	2,345.1
Cash flows from investing activities:
Proceeds from sales and maturities of marketable securities	4,063.0	2,718.9	5,190.1
Purchases of marketable securities	(6,864.9)	(3,583.1)	(3,278.1)
Acquisition of TYSABRI rights	0.0	0.0	(3,262.7)
Contingent consideration related to Fumapharm AG acquisition	(850.0)	(375.0)	(15.0)
Acquisitions of businesses	(198.8)	0.0	0.0
Purchases of property, plant and equipment	(643.0)	(287.8)	(246.3)
Other	(59.9)	(16.0)	7.3
Net cash flows used in investing activities	(4,553.6)	(1,543.0)	(1,604.7)
Cash flows from financing activities:
Purchase of treasury stock	(5,000.0)	(886.8)	(400.3)
Proceeds from issuance of stock for share-based compensation arrangements	54.2	54.9	66.8
Excess tax benefit from share-based compensation	78.2	96.4	73.5
Proceeds from borrowings	5,930.5	0.0	0.0
Repayments of borrowings	(2.1)	(2.7)	(452.4)
Other	(74.4)	(17.7)	(4.1)
Net cash flows provided by (used in) financing activities	986.4	(755.9)	(716.5)
Net increase in cash and cash equivalents	148.9	643.2	23.9
Effect of exchange rate changes on cash and cash equivalents	(45.8)	(40.9)	8.0
Cash and cash equivalents, beginning of the year	1,204.9	602.6	570.7
Cash and cash equivalents, end of the year	$ 1,308.0	$ 1,204.9	$ 602.6